Discovery of New Scaffolds for Rational Design of HCV NS5B Polymerase Inhibitors

Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of anti-HCV drugs. Here we report on the identification of novel allosteric inhibitors of HCV NS5B through a combination of structure-based virtual screening and in vitro NS5B inhibition assays. One hundred and sixty thousan...

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Détails bibliographiques
Auteurs principaux: Golub, Andriy G., Gurukumar, K. R., Basu, Amartya, Bdzhola, Volodymyr G., Bilokin, Yaroslav, Yarmoluk, Sergiy M., Lee, Jin-Ching, Talele, Tanaji T., Nichols, Daniel B., Kaushik-Basu, Neerja
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513558/
https://ncbi.nlm.nih.gov/pubmed/23127989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.010
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