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New tools for dissecting protease function: implications for inhibitor design, drug discovery and probe development

Proteases have long been considered targets for pharmaceutical development because of our deep understanding of their enzymatic mechanism and their regulatory roles in many pathologies. However, despite our ability to develop potent inhibitors, many clinical lead compounds have failed due either to...

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Autores principales: Deu, Edgar, Verdoes, Martijn, Bogyo, Matthew
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513415/
https://ncbi.nlm.nih.gov/pubmed/22218294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2203
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