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New tools for dissecting protease function: implications for inhibitor design, drug discovery and probe development
Proteases have long been considered targets for pharmaceutical development because of our deep understanding of their enzymatic mechanism and their regulatory roles in many pathologies. However, despite our ability to develop potent inhibitors, many clinical lead compounds have failed due either to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513415/ https://ncbi.nlm.nih.gov/pubmed/22218294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2203 |
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