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“Huntingtin Holiday”: Progress toward an Antisense Therapy for Huntington’s Disease
Lowering mutant Huntingtin is a consensus therapeutic strategy for Huntington’s disease. In this issue of Neuron, Kordasiewicz et al. (2012) show the benefit of transient antisense oligonucleotide (ASO) therapy to degrade Huntingtin mRNA and elicit sustained therapeutic benefit in HD mice.
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513277/ https://ncbi.nlm.nih.gov/pubmed/22726826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.06.001 |
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