Increased CD36 protein as a response to defective insulin signaling in macrophages

Accelerated atherosclerosis is a major cause of morbidity and death in insulin-resistant states such as obesity and the metabolic syndrome, but the underlying mechanisms are poorly understood. We show that macrophages from obese (ob/ob) mice have increased binding and uptake of oxidized LDL, in part...

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Hauptverfasser: Liang, Chien-Ping, Han, Seongah, Okamoto, Haruka, Carnemolla, Ronald, Tabas, Ira, Accili, Domenico, Tall, Alan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC351316/
https://ncbi.nlm.nih.gov/pubmed/14991075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419528
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