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Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

Accumulation of toxic lipids evokes the unfolded protein response (UPR) and apoptotic death of macrophages and vascular cells in atherosclerotic plaques. Primary macrophages from insulin-resistant ob/ob and insulin receptor (Insr)(−/−) mice display increased apoptosis in response to loading with fre...

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Библиографические подробности
Главные авторы: Liang, Chien-Ping, Han, Seongah, Li, Gang, Tabas, Ira, Tall, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447920/
https://ncbi.nlm.nih.gov/pubmed/22751695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1415
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