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Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis
OBJECTIVE: Insulin resistance renders macrophages more prone to cholesterol-induced apoptosis by promoting nuclear localization of transcription factor FoxO1. But FoxO1 also decreases macrophage inflammation, raising the question of how is the balance between pro-apoptotic and anti-inflammatory effe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220790/ https://ncbi.nlm.nih.gov/pubmed/21940942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.219477 |
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