Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis

OBJECTIVE: Insulin resistance renders macrophages more prone to cholesterol-induced apoptosis by promoting nuclear localization of transcription factor FoxO1. But FoxO1 also decreases macrophage inflammation, raising the question of how is the balance between pro-apoptotic and anti-inflammatory effe...

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Bibliographic Details
Main Authors: Tsuchiya, Kyoichiro, Banks, Alexander S., Liang, Chien-Ping, Tabas, Ira, Tall, Alan R., Accili, Domenico
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220790/
https://ncbi.nlm.nih.gov/pubmed/21940942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.219477
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