FoxOs Integrate Pleiotropic Actions Of Insulin In Vascular Endothelium To Protect Mice From Atherosclerosis

Atherosclerotic cardiovascular disease is the leading cause of death in insulin-resistant (type 2) diabetes. Vascular endothelial dysfunction paves the way for atherosclerosis through impaired nitric oxide availability, inflammation, and generation of superoxide. Surprisingly, we show that ablation...

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Hauptverfasser: Tsuchiya, Kyoichiro, Tanaka, Jun, Shuiqing, Yu, Welch, Carrie L., DePinho, Ronald A., Tabas, Ira, Tall, Alan R., Goldberg, Ira J., Accili, Domenico
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315846/
https://ncbi.nlm.nih.gov/pubmed/22405072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.01.018
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