Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Insulin resistance in skeletal muscle plays a major role in the development of type 2 diabetes and may be causally associated with increases in intramuscular fatty acid metabolites. Fatty acid transport protein 1 (FATP1) is an acyl-CoA synthetase highly expressed in skeletal muscle and modulates fat...

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Auteurs principaux: Kim, Jason K., Gimeno, Ruth E., Higashimori, Takamasa, Kim, Hyo-Jeong, Choi, Hyejeong, Punreddy, Sandhya, Mozell, Robin L., Tan, Guo, Stricker-Krongrad, Alain, Hirsch, David J., Fillmore, Jonathan J., Liu, Zhen-Xiang, Dong, Jianying, Cline, Gary, Stahl, Andreas, Lodish, Harvey F., Shulman, Gerald I.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2004
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC351314/
https://ncbi.nlm.nih.gov/pubmed/14991074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418917
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