Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

Using cre/loxP gene targeting, transgenic mice with muscle-specific inactivation of the GLUT4 gene (muscle GLUT4 KO) were generated and shown to develop a diabetes phenotype. To determine the mechanism, we examined insulin-stimulated glucose uptake and metabolism during hyperinsulinemic-euglycemic c...

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Principais autores: Kim, Jason K., Zisman, Ariel, Fillmore, Jonathan J., Peroni, Odile D., Kotani, Ko, Perret, Pascale, Zong, Haihong, Dong, Jianying, Kahn, C. Ronald, Kahn, Barbara B., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC353719/
https://ncbi.nlm.nih.gov/pubmed/11435467
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