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GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization

A critical defect in type 2 diabetes is impaired insulin-stimulated glucose transport and metabolism in muscle and adipocytes. To understand the metabolic adaptations this elicits, we generated mice with targeted disruption of the GLUT4 glucose transporter in both adipocytes and muscle (AMG4KO). In...

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Bibliografske podrobnosti
Main Authors: Kotani, Ko, Peroni, Odile D., Minokoshi, Yasuhiko, Boss, Olivier, Kahn, Barbara B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC529279/
https://ncbi.nlm.nih.gov/pubmed/15578099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421341
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