Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. Increased concentrations of intracellular fatty acid metabolites have been postulated to interfere with insulin signaling by activation of a serine kinase cascade involving PKCθ in sk...

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Main Authors: Choi, Cheol Soo, Fillmore, Jonathan J., Kim, Jason K., Liu, Zhen-Xiang, Kim, Sheene, Collier, Emily F., Kulkarni, Ameya, Distefano, Alberto, Hwang, Yu-Jin, Kahn, Mario, Chen, Yan, Yu, Chunli, Moore, Irene K., Reznick, Richard M., Higashimori, Takamasa, Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888566/
https://ncbi.nlm.nih.gov/pubmed/17571165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13579
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