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Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose disposal in response to insulin is impaired. We have developed a transgenic mouse with a dominant-negative...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312754/ https://ncbi.nlm.nih.gov/pubmed/11485987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.908001 |
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