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Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice
Liver IGF-1–deficient (LID) mice have a 75% reduction in circulating IGF-1 levels and, as a result, a fourfold increase in growth hormone (GH) secretion. To block GH action, LID mice were crossed with GH antagonist (GHa) transgenic mice. Inactivation of GH action in the resulting LID + GHa mice led...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC300761/ https://ncbi.nlm.nih.gov/pubmed/14702113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200417763 |
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