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Normal growth and development in the absence of hepatic insulin-like growth factor I

The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I) was a hepatically derived circulating mediator of growth hormone and is a crucial factor for postnatal growth and development. To reassess this hypothesis, we have used the Cre/loxP recombination system to delete the igf1...

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Autori principali: Yakar, Shoshana, Liu, Jun-Li, Stannard, Bethel, Butler, Andrew, Accili, Domenici, Sauer, Brian, LeRoith, Derek
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC22084/
https://ncbi.nlm.nih.gov/pubmed/10377413
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