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mTOR Inhibition Abrogates Insulin-Mediated Mammary Tumor Progression in Type 2 Diabetes
Type 2 diabetes increases breast cancer risk and mortality, and hyperinsulinemia is a major mediator of this effect. The mammalian target of rapamycin (mTOR) is activated by insulin and is a key regulator of mammary tumor progression. Pharmacological and genetic mTOR ablation suppresses tumor growth...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4082826/ https://ncbi.nlm.nih.gov/pubmed/20801951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/ERC-10-0091 |
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