Coupled Flexibility Change in Cytochrome P450cam Substrate Binding Determined by Neutron Scattering, NMR, and Molecular Dynamics Simulation

Neutron scattering and nuclear magnetic resonance relaxation experiments are combined with molecular dynamics (MD) simulations in a novel, to our knowledge, approach to investigate the change in internal dynamics on substrate (camphor) binding to a protein (cytochrome P450cam). The MD simulations ag...

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Detalhes bibliográficos
Main Authors: Miao, Yinglong, Yi, Zheng, Cantrell, Carey, Glass, Dennis C., Baudry, Jerome, Jain, Nitin, Smith, Jeremy C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512040/
https://ncbi.nlm.nih.gov/pubmed/23200050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.013
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