Coupled Flexibility Change in Cytochrome P450cam Substrate Binding Determined by Neutron Scattering, NMR, and Molecular Dynamics Simulation

Neutron scattering and nuclear magnetic resonance relaxation experiments are combined with molecular dynamics (MD) simulations in a novel, to our knowledge, approach to investigate the change in internal dynamics on substrate (camphor) binding to a protein (cytochrome P450cam). The MD simulations ag...

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Dettagli Bibliografici
Autori principali: Miao, Yinglong, Yi, Zheng, Cantrell, Carey, Glass, Dennis C., Baudry, Jerome, Jain, Nitin, Smith, Jeremy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2012
Soggetti:
Proteins and Nucleic Acids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512040/
https://ncbi.nlm.nih.gov/pubmed/23200050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.013
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