Role of Histone Deacetylases in Gene Regulation at Nuclear Lamina

Theoretical models suggest that gene silencing at the nuclear periphery may involve “closing” of chromatin by transcriptional repressors, such as histone deacetylases (HDACs). Here we provide experimental evidence confirming these predictions. Histone acetylation, chromatin compactness, and gene rep...

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Detalhes bibliográficos
Main Authors: Milon, Beatrice C., Cheng, Haibo, Tselebrovsky, Mikhail V., Lavrov, Sergei A., Nenasheva, Valentina V., Mikhaleva, Elena A., Shevelyov, Yuri Y., Nurminsky, Dmitry I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511463/
https://ncbi.nlm.nih.gov/pubmed/23226217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049692
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