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Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases the chromatin density in a fraction of topologically-associatin...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414625/ https://ncbi.nlm.nih.gov/pubmed/30862957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09185-y |
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