Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases the chromatin density in a fraction of topologically-associatin...

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Udgivet i:Nat Commun
Main Authors: Ulianov, Sergey V., Doronin, Semen A., Khrameeva, Ekaterina E., Kos, Pavel I., Luzhin, Artem V., Starikov, Sergei S., Galitsyna, Aleksandra A., Nenasheva, Valentina V., Ilyin, Artem A., Flyamer, Ilya M., Mikhaleva, Elena A., Logacheva, Mariya D., Gelfand, Mikhail S., Chertovich, Alexander V., Gavrilov, Alexey A., Razin, Sergey V., Shevelyov, Yuri Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414625/
https://ncbi.nlm.nih.gov/pubmed/30862957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09185-y
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