Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism

The polyglutamine (polyQ) diseases such as Huntington’s disease (HD), are neurodegenerative diseases caused by proteins with an expanded polyQ stretch, which misfold and aggregate, and eventually accumulate as inclusion bodies within neurons. Molecules that inhibit polyQ protein misfolding/aggregati...

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Detaylı Bibliyografya
Asıl Yazarlar: Popiel, H. Akiko, Takeuchi, Toshihide, Fujita, Hiromi, Yamamoto, Kazuhiro, Ito, Chiyomi, Yamane, Hiroshi, Muramatsu, Shin-ichi, Toda, Tatsushi, Wada, Keiji, Nagai, Yoshitaka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511362/
https://ncbi.nlm.nih.gov/pubmed/23226463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051069
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