Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism

The polyglutamine (polyQ) diseases such as Huntington’s disease (HD), are neurodegenerative diseases caused by proteins with an expanded polyQ stretch, which misfold and aggregate, and eventually accumulate as inclusion bodies within neurons. Molecules that inhibit polyQ protein misfolding/aggregati...

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Detalhes bibliográficos
Main Authors: Popiel, H. Akiko, Takeuchi, Toshihide, Fujita, Hiromi, Yamamoto, Kazuhiro, Ito, Chiyomi, Yamane, Hiroshi, Muramatsu, Shin-ichi, Toda, Tatsushi, Wada, Keiji, Nagai, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511362/
https://ncbi.nlm.nih.gov/pubmed/23226463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051069
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