Identification of PPARgamma Partial Agonists of Natural Origin (I): Development of a Virtual Screening Procedure and In Vitro Validation

BACKGROUND: Although there are successful examples of the discovery of new PPARγ agonists, it has recently been of great interest to identify new PPARγ partial agonists that do not present the adverse side effects caused by PPARγ full agonists. Consequently, the goal of this work was to design, appl...

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Detalhes bibliográficos
Main Authors: Guasch, Laura, Sala, Esther, Castell-Auví, Anna, Cedó, Lidia, Liedl, Klaus R., Wolber, Gerhard, Muehlbacher, Markus, Mulero, Miquel, Pinent, Montserrat, Ardévol, Anna, Valls, Cristina, Pujadas, Gerard, Garcia-Vallvé, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511273/
https://ncbi.nlm.nih.gov/pubmed/23226391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050816
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