Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers

The protein kinase v-akt murine thymoma viral oncogene homolog (AKT), a key regulator of cell survival and proliferation, is frequently hyperactivated in human cancers. Intramolecular pleckstrin homology (PH) domain–kinase domain (KD) interactions are important in maintaining AKT in an inactive stat...

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Main Authors: Parikh, Chaitali, Janakiraman, Vasantharajan, Wu, Wen-I, Foo, Catherine K., Kljavin, Noelyn M., Chaudhuri, Subhra, Stawiski, Eric, Lee, Brian, Lin, Jie, Li, Hong, Lorenzo, Maria N., Yuan, Wenlin, Guillory, Joseph, Jackson, Marlena, Rondon, Jesus, Franke, Yvonne, Bowman, Krista K., Sagolla, Meredith, Stinson, Jeremy, Wu, Thomas D., Wu, Jiansheng, Stokoe, David, Stern, Howard M., Brandhuber, Barbara J., Lin, Kui, Skelton, Nicholas J., Seshagiri, Somasekar
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511101/
https://ncbi.nlm.nih.gov/pubmed/23134728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204384109
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