Synthesis, Pharmacology, and Cell Biology of sn-2-Aminooxy Analogues of Lysophosphatidic Acid

[Image: see text] An efficient enantioselective synthesis of sn-2-aminooxy (AO) analogues of lysophosphatidic acid (LPA) that possess palmitoyl and oleoyl acyl chains is presented. Both sn-2-AO LPA analogues are agonists for the LPA(1), LPA(2), and LPA(4) G-protein-coupled receptors, but antagonists...

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Autori principali: Gajewiak, Joanna, Tsukahara, Ryoko, Fujiwara, Yuko, Tigyi, Gabor, Prestwich, Glenn D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510981/
https://ncbi.nlm.nih.gov/pubmed/18284246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol7030747
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