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Prions, proteinase K and infectivity
It has been described that the breakdown of β-sheets in PrP(Sc) by denaturation results in loss of infectivity and PK-sensitivity, suggesting a relationship between the structure and PK-resistance. It is also known that an important fraction of total PrP(Sc) is PK-sensitive and can be isolated by th...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510858/ https://ncbi.nlm.nih.gov/pubmed/23044510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.22309 |
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