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Prions, proteinase K and infectivity
It has been described that the breakdown of β-sheets in PrP(Sc) by denaturation results in loss of infectivity and PK-sensitivity, suggesting a relationship between the structure and PK-resistance. It is also known that an important fraction of total PrP(Sc) is PK-sensitive and can be isolated by th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510858/ https://ncbi.nlm.nih.gov/pubmed/23044510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.22309 |
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