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Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

Vascular smooth muscle cell (VSMC) tone is regulated by the state of myosin light chain (MLC) phosphorylation, which is in turn regulated by the balance between MLC kinase and MLC phosphatase (MLCP) activities. RhoA activates Rho kinase, which phosphorylates the regulatory subunit of MLC phosphatase...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kato, Mikio, Blanton, Robert, Wang, Guang-Rong, Judson, Timothy J., Abe, Yuich, Myoishi, Masafumi, Karas, Richard H., Mendelsohn, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510832/
https://ncbi.nlm.nih.gov/pubmed/23066013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421040
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