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Distinct Allostery Induced in the Cyclic GMP-binding, Cyclic GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil, and Metal Ions

The activity of many proteins orchestrating different biological processes is regulated by allostery, where ligand binding at one site alters the function of another site. Allosteric changes can be brought about by either a change in the dynamics of a protein, or alteration in its mean structure. We...

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Bibliografiska uppgifter
Huvudupphovsmän: Biswas, Kabir H., Visweswariah, Sandhya S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048737/
https://ncbi.nlm.nih.gov/pubmed/21193396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193185
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