Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma

ERK signaling regulates proliferation, survival, drug resistance, and angiogenesis in cancer. Although the mechanisms regulating ERK activation are not fully understood, we previously demonstrated that ERK phosphorylation is elevated by heparanase, an enzyme associated with aggressive behavior of ma...

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Bibliographic Details
Main Authors: Purushothaman, Anurag, Babitz, Stephen K., Sanderson, Ralph D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510827/
https://ncbi.nlm.nih.gov/pubmed/23048032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391417
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