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Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma

ERK signaling regulates proliferation, survival, drug resistance, and angiogenesis in cancer. Although the mechanisms regulating ERK activation are not fully understood, we previously demonstrated that ERK phosphorylation is elevated by heparanase, an enzyme associated with aggressive behavior of ma...

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Detalhes bibliográficos
Main Authors: Purushothaman, Anurag, Babitz, Stephen K., Sanderson, Ralph D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510827/
https://ncbi.nlm.nih.gov/pubmed/23048032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391417
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