Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype

Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing expression of proteins known to drive tumor progression (e.g. VEGF, MMP-9, hepatocyte growth factor (HGF), and RANKL). However, the mechanism whereby this enzyme regulates gene expression remains unknown. We...

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Autors principals: Purushothaman, Anurag, Hurst, Douglas R., Pisano, Claudio, Mizumoto, Shuji, Sugahara, Kazuyuki, Sanderson, Ralph D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162396/
https://ncbi.nlm.nih.gov/pubmed/21757697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254789
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