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Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase and shed syndecan-1 in the tumor microenvironment are associated with elevated angiogenesis and poor prognosis in myeloma and other cancers. To explore how the heparanase/syndecan-1 axis regulates angiogenesis, we used...

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Bibliografski detalji
Glavni autori: Purushothaman, Anurag, Uyama, Toru, Kobayashi, Fumi, Yamada, Shuhei, Sugahara, Kazuyuki, Rapraeger, Alan C., Sanderson, Ralph D.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845901/
https://ncbi.nlm.nih.gov/pubmed/20097882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-234757
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