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Engineered Disulfide-forming Amino Acid Substitutions Interfere with a Conformational Change in the Mismatch Recognition Complex Msh2-Msh6 Required for Mismatch Repair

ATP binding causes the mispair-bound Msh2-Msh6 mismatch recognition complex to slide along the DNA away from the mismatch, and ATP is required for the mispair-dependent interaction between Msh2-Msh6 and Mlh1-Pms1. It has been inferred from these observations that ATP induces conformational changes i...

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Detalhes bibliográficos
Main Authors: Hargreaves, Victoria V., Putnam, Christopher D., Kolodner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510822/
https://ncbi.nlm.nih.gov/pubmed/23045530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402495
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