Biochemical Analysis of the Human Mismatch Repair Proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)

The heterodimeric human MSH2-MSH6 protein initiates DNA mismatch repair (MMR) by recognizing mismatched bases that result from replication errors. Msh2(G674A) or Msh6(T1217D) mice that have mutations in or near the ATP binding site of MSH2 or ATP hydrolysis catalytic site of MSH6 develop cancer and...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Geng, Hui, Sakato, Miho, DeRocco, Vanessa, Yamane, Kazuhiko, Du, Chunwei, Erie, Dorothy A., Hingorani, Manju, Hsieh, Peggy
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323011/
https://ncbi.nlm.nih.gov/pubmed/22277660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316919
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk