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Biochemical Analysis of the Human Mismatch Repair Proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)

The heterodimeric human MSH2-MSH6 protein initiates DNA mismatch repair (MMR) by recognizing mismatched bases that result from replication errors. Msh2(G674A) or Msh6(T1217D) mice that have mutations in or near the ATP binding site of MSH2 or ATP hydrolysis catalytic site of MSH6 develop cancer and...

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Bibliographische Detailangaben
Hauptverfasser: Geng, Hui, Sakato, Miho, DeRocco, Vanessa, Yamane, Kazuhiko, Du, Chunwei, Erie, Dorothy A., Hingorani, Manju, Hsieh, Peggy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323011/
https://ncbi.nlm.nih.gov/pubmed/22277660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316919
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