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Biochemical Analysis of the Human Mismatch Repair Proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)
The heterodimeric human MSH2-MSH6 protein initiates DNA mismatch repair (MMR) by recognizing mismatched bases that result from replication errors. Msh2(G674A) or Msh6(T1217D) mice that have mutations in or near the ATP binding site of MSH2 or ATP hydrolysis catalytic site of MSH6 develop cancer and...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3323011/ https://ncbi.nlm.nih.gov/pubmed/22277660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316919 |
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