Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops

Insertion and deletion of small heteroduplex loops are common mutations in DNA, but why some loops are prone to mutation and others are efficiently repaired is unknown. Here we report that the mismatch recognition complex, MSH2/MSH3, discriminates between a repair-competent and a repair-resistant lo...

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Detalhes bibliográficos
Main Authors: Lang, Walter H., Coats, Julie E., Majka, Jerzy, Hura, Greg L., Lin, Yuyen, Rasnik, Ivan, McMurray, Cynthia T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198364/
https://ncbi.nlm.nih.gov/pubmed/21960445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105461108
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