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Functional Analysis of the Relationship between Vpx and the Restriction Factor SAMHD1
SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIV(SM)/HIV-2 Vpx protein. By analyzing a large panel of Vpx mutants, we identify several residues throughout the 3-helix bundle predicted for Vpx that impair both its functionality and...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510820/ https://ncbi.nlm.nih.gov/pubmed/23076149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403816 |
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