Functional Analysis of the Relationship between Vpx and the Restriction Factor SAMHD1

SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIV(SM)/HIV-2 Vpx protein. By analyzing a large panel of Vpx mutants, we identify several residues throughout the 3-helix bundle predicted for Vpx that impair both its functionality and...

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Detaylı Bibliyografya
Asıl Yazarlar: Berger, Gregory, Turpin, Jocelyn, Cordeil, Stéphanie, Tartour, Kevin, Nguyen, Xuan-Nhi, Mahieux, Renaud, Cimarelli, Andrea
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Microbiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510820/
https://ncbi.nlm.nih.gov/pubmed/23076149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403816
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