The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIV(MAC) Infection of Dendritic Cells

Two cellular factors are currently known to modulate lentiviral infection specifically in myeloid cells: SAMHD1 and APOBEC3A (A3A). SAMHD1 is a deoxynucleoside triphosphohydrolase that interferes with viral infection mostly by limiting the intracellular concentrations of dNTPs, while A3A is a cytidi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Nguyen, Xuan-Nhi, Barateau, Véronique, Wu, Nannan, Berger, Gregory, Cimarelli, Andrea
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619667/
https://ncbi.nlm.nih.gov/pubmed/26496699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140561
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