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Molecular Anatomy and Number of Antigen Specific CD8 T Cells Required to Cause Type 1 Diabetes
We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse. We used a transgenic model, in situ tetramer staining to distinguish antigen specific CD8 T cells from total T cells infiltrating islets and a var...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510245/ https://ncbi.nlm.nih.gov/pubmed/23209415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003044 |
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