The Synthesis and In Vivo Pharmacokinetics of Fluorinated Arachidonic Acid: Implications for Imaging Neuroinflammation

Arachidonic acid (AA) is found in high concentrations in brain phospholipids and is released as a second messenger during neurotransmission and much more so during neuroinflammation and excitotoxicity. Upregulated brain AA metabolism associated with neuroinflammation has been imaged in rodents using...

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Main Authors: Pichika, Rama, Taha, Ameer Y., Gao, Fei, Kotta, Kishore, Cheon, Yewon, Chang, Lisa, Kiesewetter, Dale, Rapoport, Stanley I., Eckelman, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509950/
https://ncbi.nlm.nih.gov/pubmed/22851635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.105734
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