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Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability
Chronic administration of mood stabilizers to rats downregulates the brain arachidonic acid (AA) cascade. This downregulation may explain their efficacy against bipolar disorder (BD), in which brain AA cascade markers are elevated. The atypical antipsychotics, olanzapine (OLZ) and clozapine (CLZ), a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540173/ https://ncbi.nlm.nih.gov/pubmed/23121637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12078 |
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