Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

The ubiquitin system plays an important role in trafficking of signaling receptors from the plasma membrane to lysosomes. Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains linked via lysine-48 as well as lysine-63 residues. We show that depletion of Triad1 affects th...

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Main Authors: Hassink, Gerco, Slotman, Johan, Oorschot, Viola, Van Der Reijden, Bert A., Monteferrario, Davide, Noordermeer, Sylvie M., Van Kerkhof, Peter, Klumperman, Judith, Strous, Ger J.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509441/
https://ncbi.nlm.nih.gov/pubmed/23213454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.2012778
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