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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the ability to integrate permanently into genomic DNA, thus driving long-term expression of corrective genes in all hematopoietic lineages. To date, HSC gene therapy has been successfully employed in the clin...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508510/ https://ncbi.nlm.nih.gov/pubmed/22198747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11684-011-0159-1 |
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