CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) and other forms of PKD are associated with dysregulated cell cycle and proliferation. Although no effective therapy for the treatment of PKD is currently available, possible mechanism-based approaches are beginning to emerge. A therapeutic interve...

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Hlavní autoři: Bukanov, Nikolay O., Moreno, Sarah E., Natoli, Thomas A., Rogers, Kelly A., Smith, Laurie A., Ledbetter, Steven R., Oumata, Nassima, Galons, Hervé, Meijer, Laurent, Ibraghimov-Beskrovnaya, Oxana
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507499/
https://ncbi.nlm.nih.gov/pubmed/23032260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22375
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