CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) and other forms of PKD are associated with dysregulated cell cycle and proliferation. Although no effective therapy for the treatment of PKD is currently available, possible mechanism-based approaches are beginning to emerge. A therapeutic interve...

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Auteurs principaux: Bukanov, Nikolay O., Moreno, Sarah E., Natoli, Thomas A., Rogers, Kelly A., Smith, Laurie A., Ledbetter, Steven R., Oumata, Nassima, Galons, Hervé, Meijer, Laurent, Ibraghimov-Beskrovnaya, Oxana
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507499/
https://ncbi.nlm.nih.gov/pubmed/23032260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22375
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