Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

Development of a disease‐modifying therapy to treat autosomal dominant polycystic kidney disease (ADPKD) requires well‐characterized preclinical models that accurately reflect the pathology and biochemical changes associated with the disease. Using a Pkd1 conditional knockout mouse, we demonstrate t...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Rogers, Kelly A., Moreno, Sarah E., Smith, Laurie A., Husson, Hervé, Bukanov, Nikolay O., Ledbetter, Steven R., Budman, Yeva, Lu, Yuefeng, Wang, Bing, Ibraghimov‐Beskrovnaya, Oxana, Natoli, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926022/
https://ncbi.nlm.nih.gov/pubmed/27356569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12846
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