Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity

A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate express...

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Detalhes bibliográficos
Main Authors: MacArthur, Ben D., Sevilla, Ana, Lenz, Michel, Müller, Franz-Josef, Schuldt, Berhard M., Schuppert, Andreas A., Ridden, Sonya J., Stumpf, Patrick S., Fidalgo, Miguel, Ma’ayan, Avi, Wang, Jianlong, Lemischka, Ihor R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507454/
https://ncbi.nlm.nih.gov/pubmed/23103910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2603
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