Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity

A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate express...

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Huvudupphovsmän: MacArthur, Ben D., Sevilla, Ana, Lenz, Michel, Müller, Franz-Josef, Schuldt, Berhard M., Schuppert, Andreas A., Ridden, Sonya J., Stumpf, Patrick S., Fidalgo, Miguel, Ma’ayan, Avi, Wang, Jianlong, Lemischka, Ihor R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507454/
https://ncbi.nlm.nih.gov/pubmed/23103910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2603
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