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Construction and Validation of a Regulatory Network for Pluripotency and Self-Renewal of Mouse Embryonic Stem Cells

A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse embryonic stem cells (mESCs) was extracted from several ChIP-Seq and knockdown followed by expression prior studies. The underlying regulatory logic among network components was then learned using the initia...

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Détails bibliographiques
Auteurs principaux: Xu, Huilei, Ang, Yen-Sin, Sevilla, Ana, Lemischka, Ihor R., Ma'ayan, Avi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133156/
https://ncbi.nlm.nih.gov/pubmed/25122140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003777
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